The far reaching effects of the genetic revolution on our lives as a whole make it difficult to separate the secular and sacred issues involvedIn accepting this opportunity to comment on Dr Polkinghorne’s Templeton Prize lecture, I recognise that there is a significant division between those who would see religious beliefs as irrelevant in the ethical debates concerning new biotechnologies and those who, with Dr Polkinghorne, are willing to look to the major faith traditions for insight into the nature of (...) human identity and selfhood. In secular discourse, the intrusion of religious language has long been resisted on many grounds: that sound ethical principles do not need transcendent ratification; that those who presume a privileged moral discernment derived from their religion frequently fail to appreciate the complexity of genetic and medical science; and that internecine disputes within faith communities and historically rooted incommensurabilities between them seriously compromise any prospect of consensus. This problem is tacitly acknowledged by Dr Polkinghorne himself when he notes that his willingness to accept the 14 day threshold before which certain forms of experimentation on embryos are deemed permissible would not be congenial to Roman Catholic officialdom, for whom the destruction of one life cannot be condoned even if it were to make possible the creation of another.Dialogue traversing a secular/sacred divide can be thwarted for other reasons. Those sympathetic to religious voices may concede that claims for privileged discernment are unhelpful but still insist that secular ethicists too readily fail to appreciate that religious beliefs can be constructive in strengthening motivation and in deepening commitment on ethical issues. Theologians who have served on ethics committees have sometimes expressed a sense of frustration accompanying their attempts to explain that they are starting from a different point, and working from different presuppositions, than those who …. (shrink)

In this substantial and challenging book, O’Hagan gives central place to three of Rousseau’s works—the Discourse of Inequality, the Emile, and the Social Contract—which, he says, “constitute the axes of Rousseau’s idea of formation. The formation of the human race is the axis of the Second Discourse, the formation of the individual that of the Emile, and the formation of the citizen that of the Social Contract”. However, he also draws extensively on other material, particularly Julie, ou la Nouvelle Héloïse, (...) to extend and deepen some of Rousseau’s accounts, particularly of moral and psychological issues. Such selectivity enables O’Hagan to consider in some detail each of his chosen texts, which he does with persistent intensity and rigor, in chapters 2 to 6, devoting three of these chapters to his treatment of the Social Contract. Additionally, he selects certain topics for particular attention, with individual chapters on amour-propre, on Rousseau’s views about men and women, on Rousseau’s treatment of some issues concerning language, and he closes with an extended treatment of Rousseau’s religious ideas and views about the role of religion in society. It is pleasing to see this aspect of Rousseau’s thought, which is seldom considered at length these days, dealt with with such care. Another useful aspect of O’Hagan’s discussion is that he makes available and engages with some of the ideas of leading French critics of Rousseau, which helpfully broadens the horizons of the assessments he makes. (shrink)

In this substantial and challenging book, O’Hagan gives central place to three of Rousseau’s works—the Discourse of Inequality, the Emile, and the Social Contract—which, he says, “constitute the axes of Rousseau’s idea of formation. The formation of the human race is the axis of the Second Discourse, the formation of the individual that of the Emile, and the formation of the citizen that of the Social Contract”. However, he also draws extensively on other material, particularly Julie, ou la Nouvelle Héloïse, (...) to extend and deepen some of Rousseau’s accounts, particularly of moral and psychological issues. Such selectivity enables O’Hagan to consider in some detail each of his chosen texts, which he does with persistent intensity and rigor, in chapters 2 to 6, devoting three of these chapters to his treatment of the Social Contract. Additionally, he selects certain topics for particular attention, with individual chapters on amour-propre, on Rousseau’s views about men and women, on Rousseau’s treatment of some issues concerning language, and he closes with an extended treatment of Rousseau’s religious ideas and views about the role of religion in society. It is pleasing to see this aspect of Rousseau’s thought, which is seldom considered at length these days, dealt with with such care. Another useful aspect of O’Hagan’s discussion is that he makes available and engages with some of the ideas of leading French critics of Rousseau, which helpfully broadens the horizons of the assessments he makes. (shrink)

It seems certain that one day we will allow the genetic technology which will enhance our offspring. A highly effective new tool, called CRISPR, which allows for carving out genes, is already being used to edit the genomes of animals. In July 2017, the FDA legalized that germline drugs for therapeutic purposes could be sold in the market. It is a high time, now, that we need engage in discussions about the ethics of germline intervention. To contribute to the discussion (...) by showing our thought and to educate the public, we write this paper. (shrink)

We question the usefulness of Pylyshyn's dichotomy between cognitively penetrable and cognitively impenetrable mechanisms as the basis for his distinction between cognition and early vision. This dichotomy is comparable to others that have been proposed in psychology prompting disputes that by their very nature could not be resolved. This fate is inevitable for Pylyshyn's thesis because of its reliance on internal representations and their interpretation. What is more fruitful in relation to this issue is not a difficult dichotomy, but a (...) different look at perception such as proposed by Gibson (1979). (shrink)

A laboratory-testable, solid-state Maxwell demon is proposed that utilizes the electric field energy of an open-gap p-n junction. Numerical results from a commercial semiconductor device simulator (Silvaco International–Atlas) verify primary results from a 1-D analytic model. Present day fabrication techniques appear adequate for laboratory tests of principle.

It has been suggested that early cry parameters are connected to later cognitive abilities. The present study is the first to investigate whether the acoustic features of infant cry are associated with cognitive development already during the first year, as measured by oculomotor orienting and attention disengagement. Cry sounds for acoustic analyses (fundamental frequency; F0) were recorded in two neonatal cohorts at the age of 0-8 days (Tampere, Finland) or at 6 weeks (Cape Town, South Africa). Eye tracking was used (...) to measure oculomotor orienting to peripheral visual stimuli and attention disengagement from central stimuli at 8 months (Tampere) or at 6 months (Cape Town) of age. Only a marginal positive correlation between fundamental frequency of cry (F0) and visual attention disengagement was observed in the Tampere cohort, but not in the Cape Town cohort. This correlation indicated that infants from the Tampere cohort with a higher neonatal F0 were marginally slower to shift their gaze away from the central stimulus to the peripheral stimulus. No associations between F0 and oculomotor orienting were observed in either cohort. We discuss possible factors influencing the current pattern of results suggesting a lack of replicable associations between neonatal cry and visual attention and suggest directions for future research investigating the potential of early cry analysis in predicting later cognitive development. (shrink)

The present volume contains the lectures and papers given at the 1994 international conference on hermeneutics in Halle (Germany). The conference aimed at a state of the art in the light of recent developments in science and humanities. The place in which the conference was held is renowned for its centuries-old tradition in hermeneutics and among the lectures there are indeed some devoted to this history. For the most part, however, the papers concentrate on present-day problems in fields as different (...) as comparative literature, religious studies, bible exegesis, esthetics, social sciences, intercultural dialogue. The theme of the conference, "strangeness and familiarity", reflects the tension in which any interpretation process is situated and that any theory of interpretation has to account for. The contributions to the volume are in German and French. (shrink)

Aim To ascertain the quantity and nature of gifts and items provided by the pharmaceutical industry in Australia to medical specialists and to consider whether these are appropriate in terms of justifiable ethical standards, empirical research and views expressed in the literature.

The practice of killing day-old chicks in the Dutch egg sector is a recurrent subject of societal debate. Preventing the killing of young animals and in ovo sex determination are the two main alternatives for this problem available. An online questionnaire was held to ask the opinion of the Dutch public about these alternatives. The results show that no alternative will be fully accepted, or accepted by more than half of Dutch society. However, the survey does provide an insight to (...) what people think is important for their choice: food safety and a good treatment of animals. Irrespective of the alternative chosen, these values should be safeguarded and communicated clearly. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral NS3/4A (...) protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

Amongst Kant's lesser known early writings is a short treatise with the curious title Dreams of a Spirit-Seer Explained by Dreams of Metaphysics, in which, with considerable acumen and brilliance, and not a little irony, Kant exposes the empty pretensions of his contemporary, the Swedish visionary and Biblical exegete, Emanuel Swedenborg, to have access to a spirit world, denied other mortals. Despite his efforts, it must be feared, however, that Kant did not, alas, succeed in laying the spirit of Swedenborg (...) himself to rest once and for all, for there has arisen in our own day, and within philosophy itself, a movement of thought, if such it can be called, which, like that of Swedenborg, is founded upon an unbridled and unhealthy exercise of the imagination, and apparently believes that philosophical problems can be discussed and resolved by the elaboration of fantastical, and at times repulsive, examples; if we require a name for this contemporary pretence at philosophy, we could take as our model the Italian word for science fiction, fantascienza, and call it ‘fantaphilosophy’: it is my aim to show that this fantaphilosophy is a phantom philosophy. (shrink)

The notes of W. S. Maguinness on the Corpus Tibullianum contain several things which strike me as either true or at least highly plausible. In the above passage, however, I think both he and Postgate have missed the point of the first word. Tibullus has been telling the story of how Apollo turned herdsman for love's sake. He insists several times over that it is a story, not a thing he can vouch for. The infinitives in 14 a-c make it (...) sufficiently evident that the lost pentameter began with fertur or dicitur; in 18, Artemis dicitur to have blushed for her brother's unseemly occupation; in 29, fertur that the gods used to serve Venus openly. The same line reminds us that these stories refer to old days, olim. Now comes the couplet in question. (shrink)

The extent to which Ernst Haeckel was hated and attacked by reactionary scientists, philosophers, litterateurs and preachers, is, as Lenin has pointed out in his “Materialism and Empirocriticism,” a measure of the success with which he originally expounded the results of natural science and drove them home to their logical conclusions in the interpretation of nature on a materialistic basis. Haeckel, in the days of his greatest mental vigor, made himself the spearhead of the scientific attack upon the then dominant (...) forces of theology and obscurantism, showing fearlessly how revolutionary were the results of modern science, and particularly those concerned with evolution, in altering fundamentally man's outlook upon the world in which he lived and his own nature. It has become the mode among many intellectual circles in Western countries to refer slurringly both to the more technical scientific work and to the more general reasoning of Haeckel, as being crude and out of date; but this derogation has its origin in the despair of the teleologists and is not founded in the facts of modern scientific development. Certainly, so far as genetics is concerned, the most modern results are not merely in harmony with, but brilliantly confirmatory of, those main tenets of Haeckel's general interpretation of nature which involved him in the bitterest controversy. In addition they help to show the general soundness of his more technical zoological contributions. By contrast, Haeckel's deficiencies in the realm of social affairs stand out the more strongly, although his own materialism of natural science is a necessary basis for an adequate social materialism. We will not concern ourselves here, however, with Haeckel's own social theories, but only with those in the field of natural science; it was only in the latter field that he attained his real prominence. (shrink)

Despite all the hyperbole, Natural Capitalism is not a great book and even less of a radical concept. Indeed, the "natural" is wholly unnecessary, for most of its "radical insights" amounts to nothing more than a rediscovery of the fundamental tenets of a market economy. Good capitalist entrepreneurs have always been able to figure out that pollution and waste are both inefficient and expensive. They never needed government officials or business consultants to tell them that you can do well financially (...) and environmentally at the same time. In spite of all this, if Natural Capitalism succeeds in convincing a large segment of the population that economic growth needn’t coincide with environmental degradation, it will have played a useful role—perhaps one that long-time advocates of market economies simply cannot play. One nonetheless hopes that Hawken and the Lovins will one day take a good look at what their ancestors achieved and give some credit to writers who made all of their good points—and most of their bad ones—long before they were born. (shrink)

If, as we are told, Hume's essay on Miracles was an irrelevant insertion in his Enquiry to gain it the notoriety which the Treatise had missed, the artifice has certainly been successful. Hume's thesis has been hotly debated from that day to this. Neither side it seems can claim complete victory, for both make important concessions. Green, his mostly adverse critic, agrees with Mill and L. Stephen that the argument against miracles is “irrefragable” in itself, though not consonant, he thinks, (...) with Hume's own principles: on the other hand, Huxley whilst declaring it on the historical side “irrefragable,” demurs at least to the presentation of the formal side. (shrink)

In the world as we know it to-day it may seem foolish even to speak of such a thing as justice among nations. Whatever we may say about justice within the nation—and even within nations justice seems to have disappeared over a large portion of the globe—it appears obvious that the relation of one nation to another is determined, not by justice, but by force. The state of nature so gloomily described by Hobbes as the condition out of which men (...) have emerged, a state in which there is “continual fear and danger of violent death,” seems to be embodied in the international situation as it actually exists. In such a state of war, as Hobbes remarks, “this also is consequent, that nothing can be unjust. The notions of right and wrong, justice and injustice, have there no place. Where there is no common power, there is no law; where no law, no injustice.”. (shrink)

Søren Kierkegaard published an extraordinary number of works during his lifetime, but he left behind nearly as much unpublished writing, most of which consists of what are called his "journals and notebooks." Volume 2 of this 11-volume edition of Kierkegaard's Journals and Notebooks includes materials from 1836 to 1846, a period that takes Kierkegaard from his student days to the peak of his activity as an author. In addition to containing hundreds of Kierkegaard's reflections on philosophy, theology, literature, and his (...) own personal life, these journals are the seedbed of many ideas and passages that later surfaced in Either/Or, Repetition, Fear and Trembling, Philosophical Fragments, The Concept of Anxiety, Stages on Life's Way, Concluding Unscientific Postscript, and a number of Edifying Discourses. (shrink)

BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

The aim of this paper is to provide a conceptual framework that will help in understanding and evaluating, along social and ethical lines, the issue of killing day-old male chicks and two alternative directions of responsible innovations to solve this issue. The following research questions are addressed: Why is the killing of day-old chicks morally problematic? Are the proposed alternatives morally sound? To what extent do the alternatives lead to responsible innovation? The conceptual framework demonstrates clearly that there is a (...) moral “lock-in”, and why the killing of day-old chicks is indeed an issue. Furthermore, it is shown that both alternative directions address some important objections with regard to the killing of day-old chicks, but that they also raise new dilemmas. It also becomes clear that the framework enables and secures anticipation, reflection, deliberation with and responsiveness to stakeholders, the four dimensions of responsible innovation, in a structured way. (shrink)

This revised version of Price's 1960 Gifford Lectures in two series at Aberdeen University presents an extensive analysis of the concept of belief and related problems. The author begins by exploring different senses of knowledge. He continues to examine some logical peculiarities of expressions about believing and knowing, of relationships between the two types of expressions, and remarks on the performatory aspects of the relevant expressions. Connections between believing, and the bearing on beliefs of perceptual evidence, self-consciousness, memory and testimony (...) are examined. The results of this examination are applied to introduce systematic distinctions and concepts, which are made constitutive of the concept of belief. The notion of degrees of belief is introduced. The problem of degrees of assent is examined in the context of Newman's criticisms of Locke's view. Specific theories of belief are surveyed, beginning with Hume's theory, and two traditional occurrence analyses of belief are touched upon. The first series is concluded with a brief examination of Descartes' and Hume's views on freedom of assent. The second series examines various dispositional analyses of belief; the notions of believing and "acting as if" are compared, and the connection between inference and assent examined. The notion of half-belief is reviewed, along with Newman's distinction between real and notional assent, and James' self-verifying beliefs. The second series concludes with a discussion of moral beliefs and feelings; belief "in" and belief "that" are compared, and the possibility of a rapprochement between religious belief and empiricist philosophy is examined. While the author offers no full-blown theory of belief--and does not purport to do so--he provides a most informative discussion of the matrix of epistemological and psychological problems called belief, offers new criticisms of both older and present-day views on persisting problems for belief-analysis, and refines these views with new distinctions and concepts.--J. R. H. (shrink)

Individuals make decisions under uncertainty every day. Decisions are based on in- complete information concerning the potential outcome or the predicted likelihood with which events occur. In addition, individuals’ choices often deviate from the rational or mathematically objective solution. Accordingly, the dynamics of human decision making are difficult to capture using conventional, linear mathematical models. Here, we present data from a 2-choice task with variable risk between sure loss and risky loss to illustrate how a simple nonlinear dynamical system can (...) be employed to capture the dynamics of human decision making under uncertainty (i.e., multistability, bifurcations). We test the feasibility of this model quantitatively and demonstrate how the model can account for up to 86% of the observed choice behavior. The implications of using dynamical models for explaining the nonlin- ear complexities of human decision making are discussed as well as the degree to which the theory of nonlinear dynamical systems might offer an alternative framework for understanding human decision making processes. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Scientifically derived environmental indicators are central to environmental decision analysis. This article examines the interface between science (environmental indicators) and policy, and the dilemma of their integration. In the past, science has been shown to dominate many policy debates, usually with unfavorable results. The issue, therefore, is not whether science can determine policy but how science can be part of a more holistic analysis that incorporates other critical perspectives. This article discusses the importance of considering alternative views (as represented by (...) different scientific indicators) within the policy debate. Six example ozone indicators, constructed from the same raw data, are used to illustrate this point. Two represent newly developed indicators that respond to present-day policy questions at theU.S. Environmental Protection Agency. The article concludes with a brief discussion of how such indicators can be used to better define a policy question, inform the policy debate, and evaluate policy alternatives. (shrink)

Scientifically derived environmental indicators are central to environmental decision analysis. This article examines the interface between science (environmental indicators) and policy, and the dilemma of their integration. In the past, science has been shown to dominate many policy debates, usually with unfavorable results. The issue, therefore, is not whether science can determine policy but how science can be part of a more holistic analysis that incorporates other critical perspectives. This article discusses the importance of considering alternative views (as represented by (...) different scientific indicators) within the policy debate. Six example ozone indicators, constructed from the same raw data, are used to illustrate this point. Two represent newly developed indicators that respond to present-day policy questions at the U.S. Environmental Protection Agency. The article concludes with a brief discussion of how such indicators can be used to better define a policy question, inform the policy debate, and evaluate policy alternatives. (shrink)

Individuals make decisions under uncertainty every day based on incomplete information concerning the potential outcome of the choice or chance levels. The choices individuals make often deviate from the rational or mathematically objective solution. Accordingly, the dynamics of human decision-making are difficult to capture using conventional, linear mathematical models. Here, we present data from a two-choice task with variable risk between sure loss and risky loss to illustrate how a simple nonlinear dynamical system can be employed to capture the dynamics (...) of human decision-making under uncertainty (i.e., multi-stability, bifurcations). We test the feasibility of this model quantitatively and demonstrate how the model can account for up to 86% of the observed choice behavior. The implications of using dynamical models for explaining the nonlinear complexities of human decision-making are discussed, as well as the degree to which nonlinear dynamical systems theory might offer an alternative framework for understanding human decision-making processes. (shrink)

The original CliffsNotes study guides offer expert commentary on major themes, plots, characters, literary devices, and historical background. People have not changed significantly in the many years since Aristotle first lectured on ethics at the Lyceum in Athens. The human types and problems covered in CliffsNotes on Aristotle’s Ethics are familiar to everyone. The rules of conduct and explanations of virtue and goodness that he proposes can help people of all eras better understand their role in society. This study guide (...) allows you to make your way through Aristotle’s famous essays with confidence. You’ll find clear summaries and explanations of each major theme. Other features that help you study include Introduction to the life of Aristotle Overview of the main points of Aristotle’s ethical philosophy Summaries and critical commentaries of the complete Nichomachean Ethics Review questions Classic literature or modern modern-day treasure — you'll understand it all with expert information and insight from CliffsNotes study guides. (shrink)

With improvement in medical services in the last few years, there has been a constant rise in the geriatric population throughout the world, more so in the developing countries. The elderly are highly prone to develop psychiatric disorders, probably because of age related changes in the brain, concomitant physical disorders, as well as increased stress in later life. Psychiatric disorders in this population may have a different presentation than in other groups and some of psychopathologies might be mistaken for normal (...) age related changes by an unwary clinician. Therefore the need of the day is to train psychiatrists and physicians to better recognize and manage mental disorders in this age group. (shrink)

Ethical approval must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Sixteen European national coordinators of the international study on very old intensive care patients answered an online questionnaire concerning their experience getting EA. N = 8/16 of the NCs could apply at one single national ethical committee, while the others had to apply to various regional ECs and/or individual hospital institutional research boards. The time between applying for (...) EA and the first decision varied between 7 days and 300 days. In 9/16 informed consent from the patient was not deemed necessary; in 7/16 informed consent was required from the patient or relatives. The upload of coded data to a central database required additional information in 14/16. In 4/16 the NCs had to ask separate approval to keep a subject identification code list to de-pseudonymize the patients if questions would occur. Only 2/16 of the NCs agreed that informed consent was necessary for this observational study. Overall, 6/16 of the NCs were satisfied with the entire process and 8/16 were unsatisfied. 11/16 would welcome a European central EC that would judge observational studies for all European countries. Variations in the process and prolonged time needed to get EA for observational studies hampers inclusion of patients in some European countries. This might have a negative influence on the external validity. Further harmonization of ethical approval process across Europe is welcomed for low-risk observational studies. Getting ethical approval for low-risk, non-interventional, observational studies varies enormously across European countries. (shrink)

Personal space is the distance that people tend to maintain from others during daily life in a largely unconscious manner. For humans, personal space-related behaviors represent one form of non-verbal social communication, similar to facial expressions and eye contact. Given that the changes in social behavior and experiences that occurred during the COVID-19 pandemic, including “social distancing” and widespread social isolation, may have altered personal space preferences, we investigated this possibility in two independent samples. First, we compared the size of (...) personal space measured before the onset of the pandemic to its size during the pandemic in separate groups of subjects. Personal space size was significantly larger in those assessed during the onset of the pandemic. Lastly, we found that the practice of social distancing and perceived risk of being infected with COVID-19 were linked to this personal space enlargement during the pandemic. Taken together, these findings suggest that personal space boundaries expanded during the COVID-19 pandemic independent of actual infection risk level. As the day-to-day effects of the pandemic subside, personal space preferences may provide one index of recovery from the psychological effects of this crisis. (shrink)

To attain native-like competence, second language (L2) learners must establish mappings between familiar speech sounds and new phoneme categories. For example, Spanish learners of English must learn that [d] and [ð], which are allophones of the same phoneme in Spanish, can distinguish meaning in English (i.e. /deɪ/ ‘day’ and /ðeɪ/ ‘they’). Because adult listeners are less sensitive to allophonic than phonemic contrasts in their native language (L1), novel target language contrasts between L1 allophones may pose special difficulty for L2 learners. (...) We investigate whether advanced Spanish late-learners of English overcome native language mappings to establish new phonological relations between familiar phones. We report behavioral and magnetoencepholographic (MEG) evidence from two experiments that measured the sensitivity and pre-attentive processing of three listener groups (L1 English, L1 Spanish, and advanced Spanish late-learners of English) to differences between three nonword stimulus pairs ([idi]-[iði], [idi]-[iɾi], and [iði]-[iɾi]) which differ in phones that play a different functional role in Spanish and English. Spanish and English listeners demonstrated greater sensitivity (larger d’ scores) for nonword pairs distinguished by phonemic than by allophonic contrasts, mirroring previous findings. Spanish late-learners demonstrated sensitivity (large d’ scores and MMN responses) to all three contrasts, suggesting that these L2 learners may have established a novel [d]-[ð] contrast despite the phonological relatedness of these sounds in the L1. Our results suggest that phonological relatedness influences perceived similarity, as evidenced by the results of the native speaker groups, but may not cause persistent difficulty for advanced L2 learners. Instead, L2 learners are able to use cues that are present in their input to establish new mappings between familiar phones. (shrink)

Physical activity and sedentary behaviour have been linked to the mental health of children and adolescents, yet the timing of behaviours may play a role in this relationship and clarifying this could inform interventions. We explored cross-sectional associations of PA and SED in varying time segments throughout the school day with the mental health of school-aged children and adolescents from rural Northeastern Ontario, Canada. A total of 161 students wore accelerometers for 8 days and completed a self-report survey. Mental health (...) was measured using the Strengths and Difficulties Questionnaire. Accelerometer-measured SED, light PA, and moderate and vigorous PA were estimated in the time-segments before school, school time, after school, and evenings. Associations were tested with multilevel linear regressions while adjusting for confounding factors. Students spent 72.6 min in MVPA, 209.0 min in LPA, and 621.0 min in SED per day. Daily SED was associated with less conduct problems. Evening LPA was inversely associated with hyperactivity, while SED was associated with hyperactivity and with peer problems before school, and during school. No associations were observed for MVPA, emotional symptoms, or prosocial behaviour. In conclusion, displacing SED with LPA in some specific periods of the day may benefit the mental health of students; taking this into account could strengthen interventions. (shrink)

Representing a new generation of theorists reaffirming the radical dimensions of art, Gail Day launches a bold critique of late twentieth-century art theory and its often reductive analysis of cultural objects. Exploring core debates in discourses on art, from the New Left to theories of "critical postmodernism" and beyond, Day counters the belief that recent tendencies in art fail to be adequately critical. She also challenges the political inertia that results from these conclusions. Day organizes her defense around critics who (...) have engaged substantively with emancipatory thought and social process: T. J. Clark, Manfredo Tafuri, Fredric Jameson, Benjamin H. D. Buchloh, and Hal Foster, among others. She maps the tension between radical dialectics and left nihilism and assesses the interpretation and internalization of negation in art theory. Chapters confront the claim that exchange and equivalence have subsumed the use value of cultural objects—and with it critical distance— and interrogate the proposition of completed nihilism and the metropolis put forward in the politics of Italian operaismo. Day covers the debates on symbol and allegory waged within the context of 1980s art and their relation to the writings of Walter Benjamin and Paul de Man. She also examines common conceptions of mediation, totality, negation, and the politics of anticipation. A necessary unsettling of received wisdoms, _Dialectical Passions_ recasts emancipatory reflection in aesthetics, art, and architecture. (shrink)

In this study, we explain differences in support for interreligious lawful and violent protests against the religious outgroup. Combining religiosity and social identity approaches, we take three dimensions of religiosity into consideration related to support for interreligious conflict, next to relevant control characteristics. The analysis is based on survey data collected among a random sample of Muslims and Christians across the Indonesian archipelago. Our findings show that members of the Muslim community are, on average, more inclined to support interreligious conflict, (...) both lawful and violent protests. Participation in rites of passage is a crucial aspect of religious practices found to be positively related to both kinds of protest. Religious beliefs show great importance but vary in their influence: particularistic views and intratextual fundamentalism are related to support for lawful protest, whereas religiocentrism is related to support both for lawful and violent protests. In contrast, salience reduces support for violent protest. As such, the findings offer a differentiated way to understand present-day interreligious conflicts among the general population in Indonesia. (shrink)

The legend of the encounter between Wilberforce and Huxley is well established. Almost every scientist knows, and every viewer of the BBC's recent programme on Darwin was shown,* how Samuel Wilberforce, bishop of Oxford, attempted to pour scorn on Darwin's Origin of Species at a meeting of the British Association in Oxford on 30 June 1860, and had the tables turned on him by T. H. Huxley. In this memorable encounter Huxley's simple scientific sincerity humbled the prelatical insolence and clerical (...) obscurantism of Soapy Sam; the pretension of the Church to dictate to scientists the conclusions they were allowed to reach were, for good and all, decisively defeated; the autonomy of science was established in Britain and the Western world; the claim of plain unvarnished truth on men's allegiance was vindicated, however unwelcome its implications for human vanity might be; and the flood tide of Victorian faith in all its fulsomeness was turned to an ebb, which has continued to our present day and will only end when religion and superstition have been finally eliminated from the minds of all enlightened men. Even churchmen concede that it was a disastrous defeat.1 Only Owen Chadwick strikes a note of caution, observing that the account given of the incident in Wilberforce's biography seems hardly consistent with an overwhelming defeat, and maintaining that the received account must be a largely legendary creation of a later date. (shrink)

Readers generally know only one of the two famous James brothers. Literary types know Henry James; psychologists, philosophers, and religion scholars know William James. In reality, the brothers’ minds were inseparable, as the more than eight hundred letters they wrote to each other reveal. In this book, J. C. Hallman mines the letters for mutual affection and influence, painting a moving portrait of a relationship between two extraordinary men. Deeply intimate, sometimes antagonistic, rife with wit, and on the cutting edge (...) of art and science, the letters portray the brothers’ relationship and measure the manner in which their dialogue helped shape, through the influence of their literary and intellectual output, the philosophy, science, and literature of the century that followed. William and Henry James served as each other’s muse and critic. For instance, the event of the death of Mrs. Sands illustrates what H’ry never stated: even if the “matter” of his fiction was light, the minds behind it lived and died as though it was very heavy indeed. He seemed to best understand this himself only after Wm fully fleshed out his system. “I can’t now explain save by the very fact of the spell itself . . . that [Pragmatism] cast upon me,” H’ry wrote in 1907. “All my life I have . . . unconsciously pragmatised.” Wm was never able to be quite so gracious in return. In 1868, he lashed out at the “every day” elements of two of H’ry’s early stories, and then explained: “I have uttered this long rigmarole in a dogmatic manner, as one speaks, to himself, but of course you will use it merely as a mass to react against in your own way, so that it may serve you some good purpose.” He believed he was doing H’ry a service as he criticized a growing tendency toward “over-refinement” or “curliness” of style. “I think it ought to be of use to you,” he wrote in 1872, “to have any detailed criticism fm even a wrong judge, and you don’t get much fm. any one else.” For the most part, H’ry agreed. “I hope you will continue to give me, when you can, your free impression of my performance. It is a great thing to have some one write to one of one’s things as if one were a 3d person & you are the only individual who will do this.”. (shrink)